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Big Creek Presbyterian Church is located in Rensselaer, MO. 
Rensselaer is centered between Hannibal and Monroe City, just south of Highway 36. 
Big Creek Lane (Rensselaer Rd) intersects State Highway H approximately 1.5 miles south of Highway 36. 
Big Creek Presbyterian Church is located at 49515 on the southeast intersection of Big Creek Lane and State Highway H.